This is a blog about eliminating alcohol addiction through pharmacological extinction, a process popularly known as the Sinclair Method (TSM for short).
The idea is pretty simple. Alcohol gets us high by causing the release of endorphins, which are then processed by the opioid receptors in our brains. A drug, naltrexone or sometimes nalmefene, is used to block these opioid receptors. Drinking alcohol still produces endorphins, but our brains don't receive them, and our brains gradually stop craving alcohol because the stimulus no longer produces the reward.
The cure rate is phenomenal -- 90% in studies, about 70% in the field. For an addiction treatment, that's little short of a miracle. It's far, far better than the success rate of support groups.
Join me as we address some things not well-covered and clear up some misinformation kicking around. We'll make sure to have a little fun along the way.